Crossword clues for the word: USROUTE The word USROUTE has appeared as an answer to at least 5 crossword clues on different crossword puzzles. Crossword clues for USROUTE Showing 1 to 5 of 5 results Clue(s) "Any Interstate, for example" 50 from Calif. to Md., e.g American hwy. number lead-in Hwy. number lead-in One runs from Me. to Fla.