Crossword clues for the word: UPSTREAM The word UPSTREAM has appeared as an answer to at least 9 crossword clues on different crossword puzzles. Crossword clues for UPSTREAM Showing 1 to 9 of 9 results Clue(s) Against the current. Against the flow Fishes' route. It's a hard way to swim Puts out paper opposing current tendencies River's origin Spawning salmon's course Tough way to swim Toward the source