Crossword clues for the word: UPAGAINST The word UPAGAINST has appeared as an answer to at least 5 crossword clues on different crossword puzzles. Crossword clues for UPAGAINST Showing 1 to 5 of 5 results Clue(s) ___ it (in difficulty). *Starting to encounter - ? = Situated alongside Confronted with Facing Run __ (face, as a difficulty)