Crossword clues for the word: SANTAFETRAIL The word SANTAFETRAIL has appeared as an answer to at least 5 crossword clues on different crossword puzzles. Crossword clues for SANTAFETRAIL Showing 1 to 5 of 5 results Clue(s) 19th-century trade route Historic route between Missouri and New Mexico Iron walkway that leads to the North Pole? Western relocation road? Western route