Crossword clues for the word: ROXANA The word ROXANA has appeared as an answer to at least 3 crossword clues on different crossword puzzles. Crossword clues for ROXANA Showing 1 to 3 of 3 results Clue(s) 1724 novel by Daniel Defoe subtitled The Fortunate Mistress Defoe heroine. Wife of Alexander the Great.