Crossword clues for the word: REGULUS The word REGULUS has appeared as an answer to at least 7 crossword clues on different crossword puzzles. Crossword clues for REGULUS Showing 1 to 7 of 7 results Clue(s) Big star in Leo Brightest star in Leo Brightest star in the constellation Leo Double star in Leo Huge star in Leo. Leo's bright star Star in Leo