Crossword clues for the word: OKEECHOBEE The word OKEECHOBEE has appeared as an answer to at least 11 crossword clues on different crossword puzzles. Crossword clues for OKEECHOBEE Showing 1 to 11 of 11 results Clue(s) "Locals call it the ""Big O""" "Southern lake whose name comes from Muskogean for ""big water""" Everglades lake Florida county or its seat Florida lake Florida's largest lake Fourth-largest lake completely within US borders Lake —, freshwater body of water in Florida that drains to the Atlantic Ocean via the Everglades Lake by the Everglades Large Florida lake Largest lake in Florida