Crossword clues for the word: OCTUPLE The word OCTUPLE has appeared as an answer to at least 8 crossword clues on different crossword puzzles. Crossword clues for OCTUPLE Showing 1 to 8 of 8 results Clue(s) Double three times Double x double x double Eight times as great Eightfold Expand to 800% Like an amazing return on an investment Multiply by eight Original couplet, eight times over