Crossword clues for the word: MISSIS The word MISSIS has appeared as an answer to at least 7 crossword clues on different crossword puzzles. Crossword clues for MISSIS Showing 1 to 7 of 7 results Clue(s) "A ___ as good as a mile" "Household head, perhaps" "What Sims is, when she gets married" "Wife, colloquially" I'm sis's better half Informal word for a wife Lil' lady