Crossword clues for the word: MAINISSUE The word MAINISSUE has appeared as an answer to at least 6 crossword clues on different crossword puzzles. Crossword clues for MAINISSUE Showing 1 to 6 of 6 results Clue(s) "*The economy, in many debates" Center of a debate Crux of a debate Debate focal point Debate's opening Focal topic