Crossword clues for the word: MAINFRAME The word MAINFRAME has appeared as an answer to at least 7 crossword clues on different crossword puzzles. Crossword clues for MAINFRAME Showing 1 to 7 of 7 results Clue(s) *iPad's giant ancestor Brain in many an Asimov story Computer master's at home with brother and me (9) Desktop's big brother Large computer Server alternative Source of a download