Crossword clues for the word: LOSEHEART The word LOSEHEART has appeared as an answer to at least 11 crossword clues on different crossword puzzles. Crossword clues for LOSEHEART Showing 1 to 11 of 11 results Clue(s) *Give up in despair Become despondent as Bethany would if husband left Become discouraged Become discouraged as Larwood would if wicketless Become disillusioned Begin to despair Despair as the role unravels Get discouraged Give up cryptic instructions for making better beer Give up the ales or rum? What Sandra will do to make Sara abandon hope?