Crossword clues for the word: ISSUS The word ISSUS has appeared as an answer to at least 9 crossword clues on different crossword puzzles. Crossword clues for ISSUS Showing 1 to 9 of 9 results Clue(s) "Asia Minor battle site, 333 B.C." "Battle scene, 333 B.C." "Scene of battle, 333 B.C." "Site of Darius' defeat, 333 B.C." Ancient town in Asia Minor; scene of a 333 BC battle at which Alexander the Great defeated the Persians Old town in Asia Minor Scene of an Alexander victory Where Alexander defeated Darius. Where Alexander defeated the Persians