Crossword clues for the word: ISSEX The word ISSEX has appeared as an answer to at least 2 crossword clues on different crossword puzzles. Crossword clues for ISSEX Showing 1 to 2 of 2 results Clue(s) """___ Necessary?"": Thurber-White" "James Thurber and E.B. White book ""___ Necessary?"""