Crossword clues for the word: GIST The word GIST has appeared as an answer to at least 62 crossword clues on different crossword puzzles. Crossword clues for GIST Showing 51 to 62 of 62 results Clue(s) Most vital part of some idea Nub Pith of a matter. Pith of the matter. Purposeful drift Quiddity Substance Substance or general idea The crux of marrying is trust The main point. Very heart You'll get it from CliffsNotes « Previous Next » 1 2