Crossword clues for the word: FLOTUS The word FLOTUS has appeared as an answer to at least 4 crossword clues on different crossword puzzles. Crossword clues for FLOTUS Showing 1 to 4 of 4 results Clue(s) Male C.I.C.'s better half Melania designation Michelle Obama or Jill Biden, informally White House hostess: Abbr.