Crossword clues for the word: ESOPUS The word ESOPUS has appeared as an answer to at least 4 crossword clues on different crossword puzzles. Crossword clues for ESOPUS Showing 1 to 4 of 4 results Clue(s) Hudson town south of Kingston N.Y. town on the Hudson One of New York's watershed areas Town near Kingston, N.Y.