Crossword clues for the word: DESPOND The word DESPOND has appeared as an answer to at least 7 crossword clues on different crossword puzzles. Crossword clues for DESPOND Showing 1 to 7 of 7 results Clue(s) Become disheartened. Bunyan's Slough of ___. Despair Feel extreme discouragement In the Slough of ___ (depressed) Lose heart Slough of ___