Crossword clues for the word: DESPAIRS The word DESPAIRS has appeared as an answer to at least 6 crossword clues on different crossword puzzles. Crossword clues for DESPAIRS Showing 1 to 6 of 6 results Clue(s) Abandons all hope Abandons hope Becomes discouraged when couples follow diets oddly Gives up hope. Is ready to give up the ship Loses hope