Crossword clues for the word: DEPLETE The word DEPLETE has appeared as an answer to at least 11 crossword clues on different crossword puzzles. Crossword clues for DEPLETE Showing 1 to 11 of 11 results Clue(s) Drain off Drain power during strike Empty rental in deep trouble Exhaust Exhaust (supply) Led Pete to sap Lessen drastically Reduce pressure and scrub round Use up Use up deposit for summer in Nice after July 3 Use up supplies.