Crossword clues for the word: CYO The word CYO has appeared as an answer to at least 4 crossword clues on different crossword puzzles. Crossword clues for CYO Showing 1 to 4 of 4 results Clue(s) Church-affiliated kids' grp. Rel. group founded in Chicago in 1930 Young people's org. Young persons' assn.