Crossword clues for the word: CHALLENGER The word CHALLENGER has appeared as an answer to at least 8 crossword clues on different crossword puzzles. Crossword clues for CHALLENGER Showing 1 to 8 of 8 results Clue(s) "Space shuttle in which Sally Ride became the first American woman in space (June 19, 1983)" "Space shuttle that broke apart on a 1986 mission, killing all seven crew members" Boxer who's vying for the title Champion's adversary Famed space shuttle Professor in Doyle novels. Space Shuttle —, orbiter that exploded 73 seconds after lift-off in January 1986 U.S. space shuttle