Crossword clues for the word: BREAKTHROUGH The word BREAKTHROUGH has appeared as an answer to at least 9 crossword clues on different crossword puzzles. Crossword clues for BREAKTHROUGH Showing 1 to 9 of 9 results Clue(s) "Good for a scientist, bad for a roofer" "Sudden advance, as in science" End of the factoid Important development or discovery Major development for bankrupt state? Correct! Make a sudden advance Milestone of success Penetrate (2 words) Scientific triumph.