Crossword clues for the word: BESTFRIEND The word BESTFRIEND has appeared as an answer to at least 5 crossword clues on different crossword puzzles. Crossword clues for BESTFRIEND Showing 1 to 5 of 5 results Clue(s) 2021 Saweetie song featuring 14-Across: 2 wds. Be first, perhaps, to last the person one can most depend on Be first, perhaps, to last the person you can most rely on Closest pal Mate for life?